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PUBLICATIONS

  1. I.K. Sibilska-Kaminski, R.R. Sicinski, L.A.Plum, H.F. DeLuca. Synthesis and Biological Activity of 2,22-Dimethylene Analogues of 19-Norcalcitriol and Related Compounds. J. Med. Chem. 2020, 63, 7355-7368.
     

  2. A. Fabisiak, P. Brzemiński, K. Berkowska, L. Rarova, E. Marcinkowska, R.R. Siciński. Design, synthesis and biological evaluation of novel 2-alkylidene 19-norcalcitriol analogs. Bioorg. Chem. 2020, 101, 104013.
     

  3. T.-K. Kim, V. Atigadda, P. Brzemiński, A. Fabisiak, E.K.Y. Tang, R.C. Tuckey, A.T. Slominski. Detection of 7-dehydrocholesterol and vitamin D3 derivatives in honey. Molecules, 2020, 25, 2583.
     

  4. P. Brzemiński, A. Fabisiak, K. Berkowska, L. Rarova, E. Marcinkowska, R.R. Siciński. Synthesis of Gemini analogs of 19-norcalcitriol and their platinum(II) complexes. Bioorg. Chem. 2020, 100, 103883. 
     

  5. B. Seroka, Z. Łotowski, A. Hryniewicka, L. Rarova, R.R. Siciński, A.M. Tomkiel, J.W. Morzycki. Synthesis of new cisplatin derivatives from bile acids. Molecules, 2020, 25, 655.
     

  6. A. Zep, K. Pruszkowska, Ł. Dobrzycki, K. Sęktas, P. Szałański, P.H. Marek, M.K. Cyrański, R.R. Siciński. Cholesterol based photo-switchable mesogenic dimers. Strongly bent molecules versus intercalated structure. CrystEngComm, 2019, 21, 2779-2789
     

  7. M. Misiak, W. Koźmiński, J. Wójcik, R.R. Siciński, J. Wicha. Structural analysis of 25-hydroxycholesterol stereoisomers differing in configuration in position 17 and 20, by three-dimensional NMR spectra. Steroids, 2019, 143, 49-52 
     

  8. A. Fabisiak, P. Brzemiński, K. Berkowska, E. Marcinkowska, R.R. Siciński. Synthesis of 19-norcalcitriol analogs with pegylated alkylidene chains at C-2. J. Steroid Biochem. Mol. Biol. 2019, 185, 251-255.
     

  9. A. Fabisiak, P. Brzemiński, K. Berkowska, E. Marcinkowska, R.R. Siciński. Synthesis of 19-norcalcitriol analogs with alkylidene moieties at C-2 based on succinic acid and L-methionine. J. Steroid Biochem. Mol. Biol. 2018, 177, 235-239
     

  10. P. Brzemiński, A. Fabisiak, K. Sęktas, K. Berkowska, E. Marcinkowska, R.R. Siciński. Synthesis of 19-norcalcitriol analogs with elongated side chain . J. Steroid Biochem. Mol. Biol. 2018, 177, 231-234
     

  11. M. Szybiński, P.Brzemiński, A. Fabisiak, K. Berkowska, E. Marcinkowska, R.R. Siciński. Seco-B-ring steroidal dienynes with aromatic D ring: Design, synthesis and biological evaluation. Int. J. Mol. Sci. 2017, 18, 2162
     

  12. M. Szybiński, K. Sęktas, R.R. Siciński, L.A.Plum, J. Frelek, H.F. DeLuca. Design, synthesis and biological properties of seco-D-ring modified 1α,25-dihydroxyvitamin D3 analogues. J. Steroid Biochem. Mol. Biol. 2017, 171, 144-154. 
     

  13. M. Szybiński, K. Sokołowska, R.R. Siciński, L.A. Plum, H.F. DeLuca. D-seco-Vitamin D analogs having reversed configurations at C-13 and C-14: Synthesis, docking studies and biological evaluation. J. Steroid Biochem. Mol. Biol. 2017, 173, 57-63. 
     

  14. U. Kulesza, L. A. Plum, H. F. DeLuca, A. Mouriño, R. R. Siciński. A new suprasterol by photochemical reaction of 1α ,25-dihydroxy-9-methylene-19-norvitamin D3. Org. Biomol. Chem. 2016,
     

  15. I. K. Sibilska, M. Szybiński, R. R. Siciński, L. A. Plum, H. F. DeLuca. Synthesis and biological activity of 2-methylene analogues of calcitriol and related compounds. J. Med. Chem. 2015, 58, 9653-9662.
     

  16. U. Kulesza, L. A. Plum, H. F. DeLuca, A. Mouriño, R. R. Siciński. Novel 9-alkyl- and 9-alkylidene-substituted 1α,25-dihydroxyvitamin D3 analogues: Synthesis and biological examinations. J. Med. Chem. 2015, 58, 6237-6247.
     

  17. K. Sokołowska, D. Carballa, S. Seoane, R. Perez-Fernandez, A. Mouriño, R. R. Siciński. Synthesis and biological activity of two C-7 methyl analogues of vitamin D. J. Org. Chem. 2015, 80, 165-173.
     

  18. I. K. Sibilska, R. R. Siciński, J. T. Ochalek, L. A. Plum, H. F. DeLuca. Synthesis and biological activity of 25-hydroxy-2-methylene-vitamin D3 analogues monohydroxylated in the A-ring. J . Med. Chem. 2014, 57, 8319-8331.
     

  19. K. Sokołowska, R. R. Siciński. The unusual course of the reaction of allyl phosphine oxides with the Grundmann ketone. Synthetic Communications 2014, 44, 2943-2954.
     

  20. K. Sokołowska, R. R. Siciński. Synthesis of novel vitamin D3 analog with an additional ring annulated to A and seco-B rings. Steroids 2014, 87, 67-75.
     

  21. A. Głębocka, R. R. Siciński, L. A. Plum, H. F. DeLuca. Ring-A-seco analogs of 1α ,25-dihydroxy-19-norvitamin D3.
    J. Steroid Biochem. Mol. Biol. 2013, 136, 39-43. 
     

  22. K. Sokołowska, R. R. Siciński, A. Mouriño, L. A. Plum, H. F. DeLuca. Synthesis and biological evaluation of novel 6-substituted analogs of 1α ,25-dihydroxy-19-norvitamin D3. J. Steroid Biochem. Mol. Biol. 2013, 136, 30-33.
     

  23. U. Kulesza, A. Mouriño, L. A. Plum, H. F. DeLuca, R. R. Siciński. Synthesis of novel 19-norvitamin D3 analogs with unnatural triene system. J. Steroid Biochem. Mol. Biol. 2013, 136, 23-26.
     

  24. I. K. Sibilska, R. R. Siciński, L. A. Plum, H. F. DeLuca. Synthesis and biological activity of 25-hydroxy-2-methylene-vitamin D3 compounds. J. Steroid Biochem. Mol. Biol. 2013, 136, 17-22.
     

  25. I. K. Sibilska, M. Szybiński, R. R. Siciński, L. A. Plum, H.F. DeLuca. Highly potent 2-methylene analogs of 1α ,25-dihydroxyvitamin D3: Synthesis and biological evaluation. J. Steroid Biochem. Mol. Biol. 2013, 136, 9-13.
     

  26. U. Kulesza, R. Sigüeiro, A. Mouriño, L. A. Plum, H. F. DeLuca, R. R. Siciński. Synthesis of 9-alkylated calcitriol and two 1α ,25-dihydroxy-9-methylene-10.19-dihydrovitamin D3 analogues with a non-natural triene system by thermal sigmatropic rearrangements. J. Org. Chem. 2013, 78, 1444-1450.
     

  27. A. Flores, R. R. Siciński, P. Grzywacz, J. B. Thoden, L. A. Plum, M. Clagett-Dame, H. F. DeLuca. A 20S combined with a 22R configuration markedly increases both in vivo and in vitro biological activity of 1α ,25-dihydroxy-22-methyl-2-methylene-19-norvitamin D3. J. Med. Chem. 2012, 55, 4352-4366.
     

  28. K. Plońska-Ocypa, I. Sibilska, R. R. Siciński, W. Sicińska, L. A. Plum, H. F. DeLuca, 13,13-Dimethyl-des-C,D-analogues of (20S)-1α ,25-dihydroxy-2-methylene-19-norvitamin D3 (2MD). Bioorg. Med. Chem. 2011, 19, 7205-7220.
     

  29. A. Głębocka, R. R. Siciński, L. A. Plum, H. F. DeLuca, Synthesis and biological activity of 2-(3'-hydroxypropylidene)-1α -hydroxy-19-norvitamin D analogs with shortened alkyl side chain. J. Med. Chem. 2011, 54, 6832-6842. 
     

  30. I. Sibilska, K. M. Barycka, R. R. Siciński, L. A. Plum, H. F. DeLuca, 1-Desoxy analog of 2MD: Synthesis and biological activity of (20S)-25-hydroxy-2-methylene-19-norvitamin D3. J. Steroid Biochem. Mol. Biol. 2010, 121, 51-55.
     

  31. A. Głębocka, R. R. Siciński, L. A. Plum, H. F. DeLuca, New 1α ,25-dihydroxy-19-norvitamin D3 analogs with frozen A-ring conformation. J. Steroid Biochem. Mol. Biol. 2010, 121, 46-50.
     

  32. K. Sokołowska, A. Mouriño, R. R. Siciński, L. A. Plum, H. F. DeLuca, Synthesis and biological evaluation of 6-alkylated analogs of 1α ,25-dihydroxyvitamin D3. J. Steroid Biochem. Mol. Biol. 2010, 121, 29-33.
     

  33. R. Barycki, R. R. Siciński, L. A. Plum, P. Grzywacz, M. Clagett-Dame, H. F. DeLuca. Removal of the 20-methyl group from 2-methylene-19-nor-(20S)-1α ,25-dihydroxyvitamin D3 (2MD) selectively eliminates bone calcium mobilization activity. Bioorg. Med. Chem. 2009, 17, 7658-7669. 
     

  34. A. Głębocka, K. Sokołowska, R. R. Siciński, L. A. Plum, H. F. DeLuca. New 1α ,25-dihydroxy-19-norvitamin D3 compounds constrained in a single A-ring conformation: synthesis of the analogues by ring-closing metathesis route and their biological evaluation. J. Med. Chem. 2009, 52, 3496-3504. 
     

  35. K. Płońska-Ocypa, R. R. Siciński, L. A. Plum, P. Grzywacz, J. Frelek, M. Clagett-Dame, H. F. DeLuca. 13-Methyl-substituted des-C,D-analogs of (20S)-1α ,25-dihydroxy-2-methylene-19-norvitamin D3 (2MD): synthesis and biological evaluation. Bioorg. Med. Chem. 2009, 17, 1747-1763. 
     

  36. R. R. Siciński, A. Głębocka, L. A. Plum, H. F. DeLuca. Design, synthesis, and biological evaluation of a 1α ,25-dihydroxy-19-norvitamin D3 analogue with a frozen A-ring conformation. J. Med. Chem. 2007, 50, 6154-6164. 
     

  37. A. Głębocka, R. R. Siciński, L. A. Plum, H. F. DeLuca. 2-(3'-Hydroxypropylidene)-1α-hydroxy-19-norvitamin D compounds with truncated side chains. J. Steroid Biochem. Mol. Biol. 2007, 103, 310-315. 
     

  38. E. Slatopolsky, J. L. Finch, A. J. Brown, C. S. Ritter, M. Mizobuchi, L. A. Plum, M. Clagett-Dame, R. R. Siciński, H. F. DeLuca. Effect of 2-methylene-19-nor-(20S)-1α-hydroxy-bishomopregnacalciferol (2MbisP), an analog of vitamin D, on secondary hyperparathyroidism. J. Bone Min. Res. 2007, 22, 686-694.
     

  39. K. Płońska-Ocypa, P. Grzywacz, R. R. Siciński, L. A. Plum, H. F. DeLuca. Synthesis and biological evaluation of a des-C,D-analog of 2-methylene-19-nor-1α,25-(OH)2D3. J. Steroid Biochem. Mol. Biol. 2007, 103, 298-304. 
     

  40. P. Grzywacz, L. A. Plum, R. R. Siciński, M. Clagett-Dame, H. F. DeLuca. Methyl substitution of the 25-hydroxy group on 2-methylene-19-nor-1α,25-dihydroxyvitamin D3 (2MD) reduces potency but allows bone selectivity. Arch. Biochem. Biophys. 2007, 460, 274-284.
     

  41. R. R. Siciński, A. Głębocka, L. A. Plum, H. F. DeLuca. An analog of 1α,25-dihydroxy-19-norvitamin D3 with the 1α-hydroxy group fixed in the axial position lacks biological activity in vitro. J. Steroid Biochem. Mol. Biol. 2007, 103, 293-297. 
     

  42. R. R. Siciński. 2-Alkylidene analogs of 19-nor-1α,25-(OH)2D3: synthesis and biological activity. Pol. J. Chem. 2006, 80, 573-585. 
     

  43. P. Ł. Szoka, R. R. Siciński. 19-Methyl analogs of vitamin D3: synthesis and structure elucidation by 1H NMR. Pol. J. Chem. 2006, 80, 1155-1168. 
     

  44. A. Głębocka, R. R. Siciński, L. A. Plum, M. Clagett-Dame, H. F. DeLuca. New 2-alkylidene 1α,25-dihydroxy-19-norvitamin D3 analogues of high intestinal activity: synthesis and biological evaluation of 2-(3'-alkoxypropylidene)- and 2-(3'-hydroxypropylidene) derivatives. J. Med. Chem. 2006, 49, 2909-2920. 
     

  45. A. Głębocka, R. R. Siciński, H. F. DeLuca. New derivative of 1α,25-dihydroxy-19-norvitamin D3 with 3'-alkoxypropylidene moiety at C-2: synthesis, biological activity and conformational analysis. J. Steroid Biochem. Mol. Biol. 2004, 89-90, 25-30. 
     

  46. P. Grzywacz, L. A. Plum, W. Sicińska, R. R. Siciński, J. M. Prahl, H. F. DeLuca. 2-Methylene analogs of 1α-hydroxy-19-norvitamin D3: synthesis, biological activities and docking to the ligand binding domain of the rat vitamin D receptor. J. Steroid Biochem. Mol. Biol. 2004, 89-90, 13-17. 
     

  47. L. A. Plum, J. M. Prahl, X. Ma, R. R. Siciński, S. Gowlugari, M. Clagett-Dame, H. F. DeLuca. Biologically active noncalcemic analogs of 1α,25-dihydroxyvitamin D with an abbreviated side chain containing no hydroxyl. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 6900-6904. 
     

  48. P. Grzywacz, R. R. Siciński, H. F. DeLuca. A concise synthesis of an AHR endogenous ligand with the indolecarbonyl-thiazole skeleton. Heterocycles 2003, 60, 1219-1224. 
     

  49. O. Dmitrenko, R. D. Bach, R. R. Siciński, W. Reischl. Computational insight on the effect of C(19)-substituents on [1,7]-H shift in previtamin D molecule. Theor. Chem. Acc. 2003, 109, 170-175. 
     

  50. M. Song, M. Clagett-Dame, R. E. Peterson, M. E. Hahn, W. M. Westler, R. R. Siciński, H. F. DeLuca. A ligand for the aryl hydrocarbon receptor isolated from lung. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 14694-14699. 
     

  51. R. R. Siciński, P. Rotkiewicz, A. Koliński, W. Sicińska, J. M. Prahl, C. M. Smith, H. F. DeLuca. 2-Ethyl and 2-ethylidene analogues of 1α,25-dihydroxy-19-norvitamin D3: synthesis, conformational analysis, biological activities, and docking to the modeled rVDR ligand binding domain. J. Med. Chem. 2002, 45, 3366-3380. 
     

  52. R. R. Siciński, J. M. Prahl, C. M. Smith, H. F. DeLuca. New highly calcemic 1α,25-dihydroxy-19-norvitamin D3 compounds with modified side chain: 26,27-dihomo- and 26,27-dimethylene analogs in 20S-series. Steroids 2002, 67, 247-256. 
     

  53. P. Tarnowski, P. Piątek, R. R. Siciński, J. Jurczak. Synthesis of interlocked diazacoronand system. Supramol. Chem. 2000, 12, 217-219. 
     

  54. R. R. Siciński, H. F. DeLuca. Synthesis and biological activity of 22-iodo- and (E)-20(22)-dehydro analogues of 1α,25-dihydroxyvitamin D3. Bioorg. Med. Chem. 1999, 7, 2877-2889. 
     

  55. R. R. Siciński, J. M. Prahl, C. M. Smith, H. F. DeLuca. New 1α,25-dihydroxy-19-norvitamin D3 compounds of high biological activity: synthesis and biological evaluation of 2-hydroxymethyl, 2-methyl and 2-methylene analogs. J. Med. Chem. 1998, 41, 4662-4674.
     

  56. P. Grzegorzewski, I. Koładkiewicz, J. W. Morzycki, R. R. Siciński. Synthesis and photochemical transformations of 19-phenylsulfonyl provitamin D analogue. Collect. Czech. Chem. Commun. 1998, 63, 1597-1612. 
     

  57. X. Jia, R. R. Siciński, D. M. Wellik, P. Tadikonda, H. K. Schnoes, H. F. DeLuca. Identification of a new all-trans-retinol metabolite produced through a new retinol metabolic pathway. Biochemistry 1998, 37, 5974-5980. 
     

  58. Z. Łotowski, J. W. Morzycki, R. R. Siciński. Preparation of 7 - and 7 -methylcholestane derivatives by kinetic separation of the diastereomeric mixture. Tetrahedron: Asymm. 1998, 9, 1627-1633. 
     

  59. R. R. Siciński, K. L. Perlman, J. Prahl, C. Smith, H. F. DeLuca. Synthesis and biological activity of 1α,25-dihydroxy-18-norvitamin D3 and 1 ,25-dihydroxy-18,19-dinorvitamin D3. J. Med. Chem. 1996, 39, 4497-4506. 
     

  60. K. L. Perlman, R. R. Siciński, H. M. Darwish, H. F. DeLuca. Synthesis of novel 20-oxo-pregnacalciferol analogs with binding affinity to the progesterone receptor. Bioorg. Med. Chem. Lett. 1995, 5, 2695-2700. 
     

  61. R. R. Siciński. Synthesis and photoisomerization of provitamin D analog with 11 ,19-oxide bridge. Can. J. Chem. 1995, 73, 865-872.
     

  62. R. R. Siciński, H. F. DeLuca. Synthesis of 6,7-diaza-19-norvitamin D compounds. Bioorg. Med. Chem. Lett. 1995, 5, 899-904. 
     

  63. R. R. Siciński, H. F. DeLuca. Ruthenium tetroxide oxidation of Grundmann's ketone derived from vitamin D3. Bioorg. Med. Chem. Lett. 1995, 5, 159-162. 
     

  64. R. R. Siciński, K. L. Perlman, H. F. DeLuca. Synthesis and biological activity of 2-hydroxy and 2-alkoxy analogs of 1α,25-dihydroxy-19-norvitamin D3. J. Med. Chem. 1994, 37, 3730-3738. 
     

  65. R. R. Siciński, H. F. DeLuca. Synthesis, conformational analysis, and biological activity of the 1α,25-dihydroxy-10,19-dihydrovitamin D3 isomers. Bioorg. Chem. 1994, 22, 150-171. 
     

  66. R. R. Siciński. Photochemical and thermal isomerizations of C-19 functionalized previtamin D analogs in the androstane series. Acta Chim. Hung. 1992, 129, 191-200. 
     

  67. K. L. Perlman, R. R. Siciński, H. K. Schnoes, H. F. DeLuca. 1α,25-Dihydroxy-19-nor-vitamin D3, a novel vitamin D - related compound with potential therapeutic activity. Tetrahedron Lett. 1990, 31, 1823-1824. 
     

  68. A. Kutner, K. L. Perlman, A. Lago, R. R. Siciński, H. K. Schnoes, H. F. DeLuca. Novel convergent synthesis of side chain modified analogues of 1α,25-dihydroxycholecalciferol and 1 ,25-dihydroxyergocalciferol. J. Org. Chem. 1988, 53, 3450-3457. 
     

  69. H. F. DeLuca, M. Nakada, Y. Tanaka, R. R. Siciński, M. Phelps. The plasma binding protein for vitamin D is a site of discrimination against vitamin D2 compounds by the chick. Biochim. Biophys. Acta 1988, 965, 16-21
     

  70. H. F. DeLuca, R. R. Siciński, Y. Tanaka, P. H. Stern, C. M. Smith. Biological activity of 1α,25-dihydroxyvitamin D2 and 24-epi-1α,25-dihydroxyvitamin D2. Am. J. Physiol. 1988, 254, E402-E-406.
     

  71. R. R. Siciński, W. J. Szczepek. Homoallylic rearrangement in the peracid oxidation of 19-iodo-5-androsten derivative. Tetrahedron Lett. 1987, 28, 5729-5732.
     

  72. A. Kutner, K. L. Perlman, R. R. Siciński, M. E. Phelps, H. K. Schnoes, H. F. DeLuca. Vitamin D C-22 aldehydes. New key intermediates for the synthesis of side chain modified vitamin D analogues. Tetrahedron Lett. 1987, 28, 6129-6132. 
     

  73. R. R. Siciński, H. F. DeLuca, H. K. Schnoes, Y. Tanaka, C. M. Smith.  22-Unsaturated analogs of vitamin D3 and their C(1)-hydroxylated derivatives. Bioorg. Chem. 1987, 15, 152-166. 
     

  74. R. R. Siciński, Y. Tanaka, M. Phelps, H. K. Schnoes, H. F. DeLuca. Synthesis of 25-hydroxy-[26,27-3H]vitamin D2, 1,25-dihydroxy-[26,27-3H]vitamin D2 and their (24R)-epimers. Analyt. Biochem. 1987, 161, 96-102. 
     

  75. Y. Tanaka, R. R. Siciński, H. F. DeLuca, H. Sai, N. Ikekawa. Unique rearrangement of ergocalciferol side chain in vitro: production of a biologically highly active homologue of 1α,25-dihydroxyvitamin D3. Biochemistry 1986, 25, 5512-5518. 
     

  76. J. W. Morzycki, R. R. Siciński. Synthesis of 6,7-diazacholestane derivatives. Acta Chim. Hung. 1985, 120, 239-246. 
     

  77. R. R. Siciński, Y. Tanaka, H. K. Schnoes, H. F. DeLuca. Synthesis of 1α,25-dihydroxyvitamin D2, its 24 epimer and related isomers, and their binding affinity for the 1α,25-dihydroxyvitamin D3 receptor. Bioorg. Chem. 1985, 13, 158-169. 
     

  78. J. W. Morzycki, R. R. Siciński. Unusual reactions of 8 -cyano-6,7-diazacholesterol. Heterocycles 1984, 22, 2459-2462. 
     

  79.  J. R. Jaszczyński, R. R. Siciński, W. J. Rodewald. 19-Functionalized steroids. Part IV. Mixed acetals as selective protection in androsta-5,7-diene-3 ,17 ,19-triol derivatives synthesis. Pol. J. Chem. 1984, 58, 711-720. 
     

  80. W. J. Rodewald, R. R. Siciński. 19-Functionalized steroids. Part V. Conversion of androsta-5,7-diene-3 ,17 ,19-triol derivatives into vitamin D analogs. Pol. J. Chem. 1983, 57, 1267-1274. 
     

  81. J. J. Jagodziński, R. R. Siciński. The unusual course of the reaction of 3 -acetoxylanost-5-en-7-one with p-toluenesulphonylhydrazine. Tetrahedron Lett. 1982, 23, 1837-1840. 
     

  82. J. J. Jagodziński, R. R. Siciński. Photoinduced cyclization of 3 -acetoxy-C(14a)-homo-B-norlanosta-8(14a),9(11)-diene as a route towards B(9a)-homo-C-norlanostane derivatives. Tetrahedron Lett. 1981, 22, 3901-3904. 
     

  83. W. J. Rodewald, R. R. Siciński. 19-Functionalized steroids. Part III. Intramolecular oxidative cyclization of 6 -hydroxyandrostanes with lead tetraacetate. Pol. J. Chem. 1979, 53, 131-137. 
     

  84. W. J. Rodewald, J. R. Jaszczyński, R. R. Siciński. 19-Functionalized steroids. Part II. Epimeric hemiacetal acetates as disubstitution products of 19-methyl group functionalization. Pol. J. Chem. 1978, 52, 715-719.
     

  85. W. J. Rodewald, J. R. Jaszczyński, R. R. Siciński. 19-Functionalized steroids. Part I. An improved synthesis of androst-5-ene-3 ,17 ,19-triol derivatives. Pol. J. Chem. 1978, 52, 501-509. 

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