US PATENTS

H. F. DeLuca, I. Sibilska, R. R. Siciński, L. A. Plum. Synthesis and biological activity of 2-methylene analogs of calcitriol and related compounds. U.S. Pat. No. 9,688,596 (27 June 2017)

H. F. DeLuca, L. A. Plum, R. R. Siciński, I. Sibilska, M. Clagett-Dame. 3-Desoxy-2-methylene-19-nor-vitamin D analogs and their uses. U.S. Pat. No. 8,993,547 (31 March 2015)

H. F. DeLuca, L. A. Plum, R. R. Siciński, I. Sibilska. 3-Desoxy-2-methylene-vitamin D analogs and their uses. U.S. Pat. No. 8,729,054 (20 May 2014)

H. F. DeLuca, K. M. Barycka, I. Sibilska, L. A. Plum, M. Clagett-Dame, R. Barycki, R. R. Siciński, K. Plonska-Ocypa, 1-Desoxy-2-methylene-19-norvitamin D analogs and their uses. U.S. Pat. No. 8,642,579 (4 Feb 2014)

H. F. DeLuca, I. Sibilska, L. A. Plum, M. Clagett-Dame, R. R. Siciński, K. M. Barycka, K. Plonska-Ocypa, R. Barycki. 2-Methylene-19-norvitamin D analogs and their uses. U.S. Pat. No. 8,518,917 (27 Aug 2013)

H. F. DeLuca, L. A. Plum, R. R. Siciński, I. Sibilska. 2-Methylene-vitamin D analogs and their uses. U.S. Pat. No. 8,455,467 (4 Jun 2013)

H. F. DeLuca, L. A. Plum, R. R. Siciński, I. Sibilska. 2-Methylene-vitamin D analogs and their uses. U.S. Pat. No. 8,410,080 (2 Apr 2013)

H. F. DeLuca, R. R. Siciński, L. A. Plum, M. Clagett-Dame, S. Gowlugari. 2α-Methyl-19-nor-1α-hydroxy-homopregnacalciferol and its uses. U.S. Pat. No. 8,399,438 (19 Mar 2013)

H. F. DeLuca, A. Głębocka, L. A. Plum, M. Clagett-Dame, R. R. Siciński. 19-Nor-vitamin D analogs with 1,2- or 3,2-cyclopentene ring. U.S. Pat. No. 8,217,023 (10 Jul 2012)

H. F. DeLuca, M. Clagett-Dame, L. A. Plum, R. R. Siciński, K. Płońska-Ocypa, N. J. Nieves, P. Grzywacz. 13,13-Dimethyl-des-C,D analogs of 1α,25-dihydroxy-19-norvitamin D3 compounds and topical composition dosage forms and methods of treating skin conditions thereof. U.S. Pat. No. 8,193,171 (5 Jun 2012).

H. F. DeLuca, A. Głębocka, K. Sokołowska, R. R. Siciński, L. A. Plum, M. Clagett-Dame. 6-Methylvitamin D3 analogs and their uses. U.S. Pat. No. 8,178,517 (15 May 2012)

H. F. DeLuca, R. R. Siciński, L. A. Plum, M. Clagett-Dame. 2α-Methyl-19-nor-(20S)-1α-hydroxy-bishomopregnacalciferol and its uses. U.S. Pat. No. 8,093,232 (10 Jan 2012).

H. F. DeLuca, R. R. Siciński, L. A. Plum, M. Clagett-Dame, A. Głębocka. 1α-Hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin D compounds and methods of making and treatment thereof. U.S. Pat. No. 8,058,265 (15 Nov 2011)

H. F. DeLuca, M. Clagett-Dame, L. A. Plum, A. Głębocka, R. R. Siciński. 2-Methylene-20-methyl-19,24,25,26,27-pentanor-vitamin D analogs. U.S. Pat. No. 7,943,601 (17 May 2011)

H. F. DeLuca, A. Głębocka, K. Sokołowska, R. R. Siciński, L. A. Plum, M. Clagett-Dame. 19-Nor-vitamin D analogs with 1,2-dihydrofuran ring. U.S. Pat. No. 7,879,829 (1 Feb 2011)

H. F. DeLuca, A. Głębocka, R. R. Siciński, A. Plum. 1α-Hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin D compounds with a 1,1-dimethylpropyl side chain. U.S. Pat. No. 7,763,598 (27 Jul 2010)

H. F. DeLuca, R. Barycki, P. K. Grzywacz, L. A. Plum, R. R. Siciński, M. Clagett-Dame. 2-Alkylidene-18,19-dinor-vitamin D compounds. U.S. Pat. No. 7,713,951 (11 May 2010)

H. F. DeLuca, A. Głębocka, K. Sokołowska, R. R. Siciński, L. A. Plum, M. Clagett-Dame. 19-Nor-vitamin D analogs with 3,2-dihydrofuran ring. U.S. Pat. No. 7,648,974 (9 Jan 2010)

H. F. DeLuca, R. R. Siciński, A. Głębocka, L. A. Plum, M. Clagett-Dame. 19-Nor-vitamin D analogs with 1,2 or 3,2 heterocyclic ring. U.S. Pat. No. 7,538,098 (26 May 2009).

H. F. DeLuca, K. Płońska-Ocypa, R. R. Siciński, P. Grzywacz, L. A. Plum, M. Clagett-Dame. Des-C,D analogs of 1α,25-dihydroxy-19-norvitamin D3. U.S. Pat. No. 7,534,777 (19 May 2009).

H. F. DeLuca, R. R. Siciński, A. Głębocka, A. Plum. 2-Propylidene-19-nor-vitamin D compounds. U.S. Pat. No. 7,531,527 (12 May 2009).

H. F. DeLuca, R. R. Siciński. 2-Ethyl and 2-ethylidene-19-nor-vitamin D compounds. U.S. Pat. No. 7,468,361 (23 Dec 2008).

H. F. DeLuca, R. R. Siciński. 2-Ethyl and 2-ethylidene-19-nor-vitamin D compounds. U.S. Pat. No. 7,300,925 (27 Nov 2007).

H. F. DeLuca, P. K. Grzywacz, R. R. Siciński. Synthesis of indole thiazole compounds as ligands for the Ah receptor. U.S. Pat. No. 7,241,900 (10 Jul 2007).

H. F. DeLuca, R. R. Siciński, L. A. Plum, M. Clagett-Dame. 2α-Methyl-19-nor-(20S)-1α-hydroxy-bishomopregnacalciferol and its uses. U.S. Pat. No. 7,241,751 (10 Jul 2007).

H. F. DeLuca, R. R. Siciński, A. Głębocka, A. Plum. 2-Propylidene-19-nor-vitamin D compounds. U.S. Pat. No. 7,241,747 (10 Jul 2007).

H. F. DeLuca, R. R. Siciński, S. Gowlugari. 2-Methylene-19-nor-vitamin D2 compounds. U.S. Pat. No. 7,232,810 (19 Jun 2007)

H. F. DeLuca, S. Gowlugari, R. R. Siciński. Method of synthesizing 1α-hydroxy-2-methylene-19-nor-homopregnacalciferol. U.S. Pat. No. 7,208,484 (24 Apr 2007).

H. F. DeLuca, R. R. Siciński, P. K. Grzywacz. (20S)-1α-Hydroxy-2α-methyl and 2α-methyl-19-nor-vitamin D3 and their uses. U.S. Pat. No. 7,205,286 (17 Apr 2007).

H. F. DeLuca, R. R. Siciński. 2-Ethyl and 2-ethylidene-19-nor-vitamin D compounds. U.S. Pat. No. 7,141,558 (28 Nov 2006).

H. F. DeLuca, R. R. Siciński. 26,27-Homologated-20-epi-2-alkyl-19-nor-vitamin D compounds. U.S. Pat. No. 7,112,579 (26 Sept 2006).

H. F. DeLuca, R. R. Siciński, P. K. Grzywacz. (20S)-1 -Hydroxy-2 -methyl and 2 -methyl-19-nor-vitamin D3 and their uses. U.S. Pat. No. 7,094,916 (22 Aug 2006).

H. F. DeLuca, R. R. Siciński. Method of locking 1α-OH of vitamin D compounds in axial orientation. U.S. Pat. No. 7,094,776 (22 Aug 2006).

H. F. DeLuca, R. R. Siciński. 26,27-Homologated-20-epi-2-alkylidene-19-nor-vitamin D compounds. U.S. Pat. No. 7,094,774 (22 Aug 2006).

H. F. DeLuca, R. R. Siciński. Method of locking 1α-OH of vitamin D compounds in axial orientation. U.S. Pat. No. 7,071,179 (4 Jul 2006).

H. F. DeLuca, R. R. Siciński, P. K. Grzywacz. (20S)-1α-Hydroxy-2α-methyl and 2α-methyl-19-nor-vitamin D3 and their uses. U.S. Pat. No. 7,064,115 (20 June 2006).

H. F. DeLuca, R. R. Siciński. Method of locking 1α-OH of vitamin D compounds in axial orientation. U.S. Pat. No. 7,056,904 (6 Jun 2006).

H. F. DeLuca, P. K. Grzywacz, R. R. Siciński. Synthesis of indole thiazole compounds as ligands for the Ah receptor. U.S. Pat. No. 7,002,019 (21 Feb 2006).

H. F. DeLuca, R. R. Siciński. 2-Ethyl and 2-ethylidene-19-nor-vitamin D compounds. U.S. Pat. No. 6,992,074 (31 Jan 2006).

H. F. DeLuca, J. Song, M. Clagett-Dame, R. E. Peterson, W. M. Westler, R. R. Siciński. Preparations and use of an Ah receptor ligand, 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester. U.S. Pat. No. 6,916,834 (12 July 2005).

H. F. DeLuca, R. R. Siciński. Method of locking 1α-OH of vitamin D compounds in axial orientation. U.S. Pat. No. 6,890,914 (10 May 2005).

H. F. DeLuca, R. R. Siciński, P. K. Grzywacz. (20S)-1α-Hydroxy-2α-methyl and 2α-methyl-19-nor-vitamin D3 and their uses. U.S. Pat. No. 6,846,811 (25 Jan 2005).

H. F. DeLuca, R. R. Siciński, P. K. Grzywacz. (20S)-1α-Hydroxy-2α-methyl and 2α-methyl-19-nor-vitamin D3 and their uses. U.S. Pat. No. 6,844,457 (18 Jan 2005).

H. F. DeLuca, R. R. Siciński, P. K. Grzywacz. (20S)-1α-Hydroxy-2α-methyl and 2α-methyl-19-nor-vitamin D3 and their uses. U.S. Pat. No. 6,844,332 (18 Jan 2005).

H. F. DeLuca, R. R. Siciński, P. K. Grzywacz. (20S)-1α-Hydroxy-2α-methyl and 2α-methyl-19-nor-vitamin D3 and their uses. U.S. Pat. No. 6,844,331 (18 Jan 2005).

H. F. DeLuca, R. R. Siciński, P. K. Grzywacz, (20S)-1α-Hydroxy-2α-methyl and 2α-methyl-19-nor-vitamin D3 and their uses. U.S. Pat. No. 6,844,330 (18 Jan 2005).

H. F. DeLuca, R. R. Siciński. 2-Ethyl and 2-ethylidene-19-nor-vitamin D compounds. U.S. Pat. No. 6,806,262 (19 Oct 2004).

H. F. DeLuca, S. Gowlugari, R. R. Siciński. Method of synthesizing 1 -hydroxy-2-methylene-19-nor-homopregnacalciferol. U.S. Pat. No. 6,774,251 (10 Aug 2004).

H. F. DeLuca, R. R. Siciński. 26,27-Homologated-20-epi-2-alkylidene-19-nor-vitamin D compounds. U.S. Pat. No. 6,696,431 (24 Feb 2004).

H. F. DeLuca, R. R. Siciński. 26,27-Homologated-20-epi-2-alkyl-19-nor-vitamin D compounds. U.S. Pat. No. 6,667,298 (23 Dec 2003).

H. F. DeLuca, R. R. Siciński, S. Gowlugari, L. A. Plum, M. Clagett-Dame. 1α-Hydroxy-2-methylene-19-nor-homopregnacalciferol and its uses. U.S. Pat. No. 6,579,861 (17 Jun 2003).

H. F. DeLuca, R. R. Siciński. 26,27-Homologated-20-epi-2-alkyl-19-nor-vitamin D compounds. U.S. Pat. No. 6,544,969 (08 Apr 2003).

H. F. DeLuca, R. R. Siciński. 26,27-Homologated-20-epi-2-alkylidene-19-nor-vitamin D compounds. U.S. Pat. No. 6,537,981 (25 Mar 2003).

H. F. DeLuca, R. R. Siciński. Method of locking 1α-OH of vitamin D compounds in axial orientation. U.S. Pat. No. 6,506,912 (14 Jan 2003).

H. F. DeLuca, R. R. Siciński. Method of locking 1α-OH of vitamin D compounds in axial orientation. U.S. Pat. No. 6,482,812 (19 Nov 2002).

H. F. DeLuca, R. R. Siciński, H. Holden, J. B. Thoden. Crystalline 1α-hydroxyvitamin D2 and method of purification thereof. U.S. Pat. No. 6,462,031 (08 Oct 2002).

H. F. DeLuca, R. R. Siciński. Method of locking 1α-OH of vitamin D compounds in axial orientation. U.S. Pat. No. 6,458,827 (01 Oct 2002).

H. F. DeLuca, R. R. Siciński, S. Gowlugari, L. A. Plum, M. Clagett-Dame. 1α-Hydroxy-2-methylene-19-nor-homopregnacalciferol and its uses. U.S. Pat. No. 6,440,953 (27 Aug 2002).

H. F. DeLuca, R. R. Siciński, H. Holden, J. B. Thoden. Crystalline 1α-hydroxyvitamin D2 and method of purification thereof. U.S. Pat. No. 6,432,936 (13 Aug 2002).

H. F. DeLuca, R. R. Siciński. 26,27-Homologated-20-epi-2-alkylidene-19-nor-vitamin D compounds. U.S. Pat. No. 6,392,071 (21 May 2002).

H. F. DeLuca, R. R. Siciński. Method of locking 1α-OH of vitamin D compounds in axial orientation. U.S. Pat. No. 6,369,099 (09 Apr 2002).

H. F. DeLuca, R. R. Siciński, H. Holden, J. B. Thoden. Crystalline 1α,24(S)-dihydroxyvitamin D2 and method of purification thereof. U.S. Pat. No. 6,362,350 (26 Mar 2002).

H. F. DeLuca, R. R. Siciński. 26,27-Homologated-20-epi-2-alkyl-19-nor-vitamin D compounds. U.S. Pat. No. 6,316,642 (13 Nov 2001).

H. F. DeLuca, R. R. Siciński. 2-Alkyl-19-nor-vitamin D compounds. U.S. Pat. No. 6,277,837 (21 Aug 2001).

H. F. DeLuca, R. R. Siciński. 2-Alkyl-19-nor-vitamin D compounds. U.S. Pat. No. 6,127,559 (03 Oct. 2000).

H. F. DeLuca, R. R. Siciński. Method of locking 1α-OH of vitamin D compounds in axial orientation. U.S. Pat. No. 6,114,317 (05 Sept 2000).

H. F. DeLuca, R. R. Siciński. 2-Alkyl-19-nor-vitamin D compounds. U.S. Pat. No. 5,945,410 (31Aug 1999).

H. F. DeLuca, R. R. Siciński. 2-Alkylidene-19-nor-vitamin D compounds. U.S. Pat. No. 5,936,133 (10 Aug 1999).

H. F. DeLuca, H. K. Schnoes, R. R. Siciński, Xiujuan Jia. All-trans-retinol metabolite. U.S. Pat. No. 5,880,292 (09 Mar 1999).

H. F. DeLuca, H. K. Schnoes, K. L. Perlman, R. R. Siciński, J. M. Prahl. 19-Nor-vitamin D compounds. U.S. Pat. No. 5,880,113 (09 Mar 1999).

H. F. DeLuca, R. R. Siciński. 2-Alkylidene-19-nor-vitamin D compounds. U.S. Pat. No. 5,843,928 (01 Dec 1998).

H. F. DeLuca, R. R. Siciński, K. L. Perlman. 18,19-Dinor-vitamin D compounds. U.S. Pat. No. 5,843,927 (01 Dec 1998).

H. F. DeLuca, R. R. Siciński, K. L. Perlman. 18-Nor-vitamin D compounds. U.S. Pat. No. 5,767,111 (16 June 1998).

H. F. DeLuca, R. R. Siciński, K. L. Perlman. 18,19-Dinor-vitamin D compounds. U.S. Pat. No. 5,756,489 (26 May 1998).

H. F. DeLuca, R. R. Siciński, K. L. Perlman. 18,19-Dinor-vitamin D compounds. U.S. Pat. No. 5,721,225 (24 Feb 1998).

H. F. DeLuca, R. R. Siciński, K. L. Perlman. Method of treating metabolic bone diseases with 18-nor-vitamin D compounds. U.S. Pat. No. 5,721,224 (24 Feb 1998).

H. F. DeLuca, H. K. Schnoes, K. L. Perlman, R. R. Siciński, J. M. Prahl. 19-Nor-vitamin D compounds. U.S. Pat. No. 5,710,294 (20 Jan 1998).

H. F. DeLuca, R. R. Siciński, K. L. Perlman. 18-Nor-vitamin D compounds. U.S. Pat. No. 5,661,140 (26 Aug 1997).

H. F. DeLuca, H. K. Schnoes, K. L. Perlman, R. R. Siciński, J. M. Prahl. 19-Nor-vitamin D compounds. U.S. Pat. No. 5,633,241 (27 May 1997).

H. F. DeLuca, H. K. Schnoes, K. L. Perlman, R. R. Siciński, J. M. Prahl. 19-Nor-vitamin D compounds. U.S. Pat. No. 5,618,805 (08 Apr 1997).

H. F. DeLuca, K. L. Perlman, R. R. Siciński, H. M. Darwish. 20-Oxo-pregnacalciferol analogs with binding affinity to the progesterone receptor. U.S. Pat. No. 5,614,512 (25 Mar 1997).

H. F. DeLuca, H. K. Schnoes, K. L. Perlman, R. R. Siciński, J. M. Prahl. 19-Nor-vitamin D compounds. U.S. Pat. No. 5,587,497 (24 Dec 1996).

H. F. DeLuca, R. R. Siciński. 17-Formyl-5,6-trans-vitamin D compounds. U.S. Pat. No. 5,565,589 (15 Oct 1996).

H. F. DeLuca, H. K. Schnoes, K. L. Perlman, R. R. Siciński, J. M. Prahl. Method of treating proliferative skin disorders with 19-nor-vitamin D compounds. U.S. Pat. No. 5,561,123 (01 Oct 1996).

H. F. DeLuca, R. R. Siciński. (E)-20(22)-Dehydro Diels-Alder compounds. U.S. Pat. No. 5,536,828 (16 Jul 1996).

H. F. DeLuca, K. L. Perlman, R. R. Siciński. 19-Nor-vitamin D3 compounds with substituent at 2-position. U.S. Pat. No. 5,536,713 (16 Jul 1996).

H. F. DeLuca, R. R. Siciński. Method of treating metabolic bone disease with (E)-20(22)-dehydrovitamin D compounds. U.S. Pat. No. 5,488,044 (30 Jan 1996).

H. F. DeLuca, R. R. Siciński. (E)-20(22)-Dehydrovitamin D compounds. U.S. Pat. No. 5,484,782 (16 Jan 1996).

H. F. DeLuca, R. R. Siciński. (E)-20(22)-Dehydrovitamin D compounds. U.S. Pat. No. 5,484,781 (16 Jan 1996).

H. F. DeLuca, R. R. Siciński. Iodo vitamin D3 compounds and method for preparing same. U.S. Pat. No. 5,380,720 (10 Jan 1995).

H. F. DeLuca, R. R. Siciński. Iodo vitamin D3 compounds and method for preparing same. U.S. Pat. No. 5,371,249 (06 Dec 1994).

H. F. DeLuca, H. K. Schnoes, K. L. Perlman, R. R. Siciński, J. M. Prahl. 19-Nor-vitamin D compounds. U.S. Pat. No. 5,342,975 (30 Aug 1994).

H. F. DeLuca, H. K. Schnoes, K. L. Perlman, R. R. Siciński. J. M. Prahl, 19-Nor-vitamin D compounds for use in treating hyperparathyroidism. U.S. Pat. No. 5,246,925 (21 Sep 1993).

H. F. DeLuca, H. K. Schnoes, K. L. Perlman, R. R. Siciński, J. M. Prahl. 19-Nor-vitamin D compounds. U.S. Pat. No. 5,237,110 (17 Aug 1993).

H. F. DeLuca, H. K. Schnoes, R. R. Siciński, Y. Tanaka. Process for the preparation of 1α,25-dihydroxylated vitamin D2 and related compounds. U.S. Pat. No. 5,036,061 (30 Jul 1991).

H. F. DeLuca, H. K. Schnoes, A. Kutner, K. L. Perlman, R. R. Siciński, M. E. Phelps. Vitamin D related compounds and processes for their preparation. U.S. Pat. No. 4,847,012 (11 Jul 1989).

H. F. DeLuca, H. K. Schnoes, R. R. Siciński, Y. Tanaka. 1α,25-dihydroxyvitamin D2 compounds. U.S. Pat. No. 4,769,181 (06 Sep 1988).

H. F. DeLuca, H. K. Schnoes, R. R. Siciński, Y. Tanaka. Side-chain unsaturated 1α-hydroxyvitamin D compounds. U.S. Pat. No. 4,719,205 (12 Jan 1988).

H. F. DeLuca, H. K. Schnoes, R. R. Siciński, Y. Tanaka. Fowl bone mineralization with 28-nor 1α-hydroxyvitamin D2 analogs. U.S. Pat. No. 4,719,204 (12 Jan 1988).

H. F. DeLuca, H. K. Schnoes, R. R. Siciński, Y. Tanaka. 1α,25-Dihydroxy-22Z-dehydrovitamin D compound. U.S. Pat. No. 4,689,180 (25 Aug 1987).

H. F. DeLuca, H. K. Schnoes, R. R. Siciński, Y. Tanaka. Hydroxyvitamin D2 isomers. U.S. Pat. No. 4,505,906 (19 Mar 1985).